Methods for Studying Site-Specific O-GlcNAc Modifications: Successes, Limitations, and Important Future Goals
Stuart P. Moon, Afraah Javed, Eldon R. Hard, Matthew R. Pratt
Abstract
, each with their own respective strengths and shortcomings. Together, they comprise a potent chemical biology toolbox for the analysis of O-GlcNAcylation (and, in theory, other post-translational modifications) while highlighting the need and space for more facile, generalizable, and biologically authentic techniques.
Topics & Concepts
Posttranslational modificationComputational biologyToolboxChemical biologyChemical spaceFunction (biology)Protein functionChemistryComputer scienceNanotechnologyBiologyBiochemistryDrug discoveryCell biologyMaterials scienceEnzymeGeneProgramming languageGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisPeptidase Inhibition and Analysis