Exploiting the Natural Diversity of RhlA Acyltransferases for the Synthesis of the Rhamnolipid Precursor 3-(3-Hydroxyalkanoyloxy)Alkanoic Acid
Andrea Germer, Till Tiso, Conrad Müller, Beate Behrens, Christian Vosse, Karen Scholz, Matti Froning, Heiko Hayen, Lars M. Blank
Abstract
The RhlA specificity explains the observed differences in 3-(3-hydroxyalkanoyloxy)alkanoic acid (HAA) congeners. Whole-cell catalysts can now be designed for the synthesis of different congener mixtures of HAAs and rhamnolipids, thereby contributing to the envisaged synthesis of designer HAAs.
Topics & Concepts
GammaproteobacteriaBurkholderiaContext (archaeology)MicrobiologyEscherichia coliBiologyChemistryBiochemistryBacteriaGeneGenetics16S ribosomal RNAPaleontologyMicrobial bioremediation and biosurfactantsMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and Immobilization