Litcius/Paper detail

Protocol for assessing ex vivo lipolysis of murine adipose tissue

Debasish Roy, Julia M. Myers, Andrea Tedeschi

2022STAR Protocols17 citationsDOIOpen Access PDF

Abstract

Here, we provide a detailed protocol for assessing ex vivo lipolysis of subcutaneous and visceral white adipose tissue. We describe a robust approach to detect depot-specific changes in lipolytic potential under basal and beta-adrenergic receptor-stimulated conditions. Given that adipose tissue plays a critical role in systemic metabolic health, this experimental protocol can be used to determine changes in adipose tissue function in health and disease.

Topics & Concepts

LipolysisAdipose tissueEx vivoWhite adipose tissueIn vivoInternal medicineEndocrinologyMedicineBiologyBiotechnologyAdipose Tissue and MetabolismLipid metabolism and biosynthesisAdipokines, Inflammation, and Metabolic Diseases