CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in <i>TP53</i>
Karlo Perica, Nayan Jain, Michael Scordo, Ruchi Patel, Özgür Can Eren, Utsav Patel, Gunes Gundem, Dylan Domenico, Sneha Mitra, Nicholas D. Socci, J.K. Everett, Aoife M. Roche, Angelina Petrichenko, Gunjan L. Shah, Maria E. Arcila, Laetitia Borsu, Jae H. Park, Steven M. Horwitz, Sergio Giralt, Ahmet Doǧan, Christina C. Leslie, Elli Papaemmanuil, Frederic D. Bushman, Saad Z. Usmani, Michel Sadelain, Sham Mailankody
Abstract
, which developed in a patient with multiple myeloma after B-cell maturation antigen (BCMA) CAR T-cell therapy.
Topics & Concepts
Chimeric antigen receptorLymphomaAntigenCancer researchBCL10ImmunologyVirologyT cellMedicineBiologyImmune systemCAR-T cell therapy researchLymphoma Diagnosis and TreatmentChronic Lymphocytic Leukemia Research