NMR-based serum and urine metabolomic profile reveals suppression of mitochondrial pathways in experimental sepsis-associated acute kidney injury
Stephen W. Standage, Shenyuan Xu, Lauren Brown, Qing Ma, Adeleine Koterba, Patrick Lahni, Prasad Devarajan, Michael A. Kennedy
Abstract
NMR-based metabolomics revealed disruptions in branched-chain amino acid metabolism, fatty acid oxidation, and NAD + synthesis in sepsis-associated acute kidney injury. These pathways represent essential processes for energy provision in renal tubular epithelial cells and may represent targetable mechanisms for therapeutic intervention.
Topics & Concepts
SepsisAcute kidney injuryKidneyCreatinineRenal functionInflammationPathophysiologyKidney diseaseMetabolomicsMedicineInternal medicineBiologyEndocrinologyBioinformaticsMetabolomics and Mass Spectrometry StudiesSepsis Diagnosis and TreatmentAcute Kidney Injury Research