Breathable and Stretchable Dressings for Accelerating Healing of Infected Wounds
Le Wang, Wenfu Zheng, Qinghong Hou, Leni Zhong, Qizhen Li, Xingyu Jiang
Abstract
Multidrug-resistant (MDR) bacteria-infected wounds are challenging issues that threaten human health. Herein, L-thioproline (T) and Boc-capped L-thioproline (BT)-decorated gold nanoparticles (TBT-GNPs) with potent antibacterial activity against MDR bacteria are reported. The TBT-GNPs are composited with bacterial cellulose to form wound dressings which show excellent antimicrobial performance both in vitro and in vivo. Moreover, this dressing is both breathable and stretchable which is favorable for gas exchange to accelerate the wound healing. This work is insightful for developing multifunctional dressings to satisfy the clinical requirements.
Topics & Concepts
AntimicrobialIn vivoWound healingBacteriaMicrobiologyMaterials scienceMedicineBiologyBiotechnologyImmunologyGeneticsAntimicrobial agents and applicationsAntimicrobial Peptides and ActivitiesWound Healing and Treatments