Soluble RAGE and skeletal muscle tissue RAGE expression profiles in lean and obese young adults across differential aerobic exercise intensities
Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Alec Chaves, Kelly N. Z. Fuller, Ryan K. Perkins, Andrew T. Ludlow, Jacob M. Haus
Abstract
This study is the first to investigate the effects of aerobic exercise intensity on circulating sRAGE isoforms, muscle RAGE protein, and muscle RAGE splicing. sRAGE isoforms tended to diminish with exercise, although this effect was attenuated with increasing exercise intensity. Muscle RAGE protein and gene expression were unaffected by exercise. However, individuals with obesity displayed nearly twofold higher muscle RAGE protein and gene expression, which positively correlated with expression of the P65 subunit of NF-κB.
Topics & Concepts
Rage (emotion)EndocrinologyInternal medicineAerobic exerciseMedicineGlycationInflammationReceptorType 2 diabetesDiabetes mellitusBiologyNeuroscienceAdvanced Glycation End Products researchDiabetes, Cardiovascular Risks, and LipoproteinsChronic Obstructive Pulmonary Disease (COPD) Research