Impacts of polyethylene glycol (PEG) dispersity on protein adsorption, pharmacokinetics, and biodistribution of PEGylated gold nanoparticles
Xinsheng Tian, Yumin Yuan
Abstract
Monodisperse PEG-AuNPs in blood vessels can avoid being rapidly cleared by the reticuloendothelial system and thus accumulate in tumor tissue.
Topics & Concepts
Polyethylene glycolBiodistributionPEG ratioDispersityPharmacokineticsMononuclear phagocyte systemClearanceChemistryNanoparticlePEGylationColloidal goldAdsorptionChromatographyNuclear chemistryPharmacologyMaterials scienceNanotechnologyOrganic chemistryIn vitroBiochemistryMedicineEconomicsImmunologyFinanceUrologyNanoparticle-Based Drug DeliveryGraphene and Nanomaterials ApplicationsNanoplatforms for cancer theranostics