Ruthenium(II)–Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis
Jakub Červinka, Alberto Gobbo, Lorenzo Biancalana, Lenka Marková, Vojtěch Novohradský, Massimo Guelfi, Stefano Zacchini, Jana Kašpárková, Viktor Brabec, Fabio Marchetti
Abstract
and significant selectivity toward cancer cells. The tested compounds effectively accumulate in cancer cells, and mitochondria represent a significant target of biological action. Most notably, data provide convincing evidence that the mechanism of biological action is mediated by the inhibiting of mitochondrial calcium intake.
Topics & Concepts
ChemistryTrisCalciumRutheniumMitochondrionHomeostasisCell growthCell biologyBiochemistryCatalysisOrganic chemistryBiologyMetal complexes synthesis and propertiesClick Chemistry and ApplicationsFerrocene Chemistry and Applications