Radical deuteration
Li Nian, Yantao Li, Xiaopeng Wu, Chengjian Zhu, Jin Xie
Abstract
Deuterated chemicals are becoming irreplaceable in pharmaceutical engineering, material science and synthetic chemistry. Many excellent reviews have discussed acid/base-dependent or metal-catalyzed deuteration reactions, but radical deuterations have been discussed less. With the development of radical chemistry, there has been a rapid growth in radical deuterium-labelling technology. Diverse mild, cheap and efficient strategies for deuterium atom installation have been reported, and this review summarizes the recent achievements of radical deuteration classified by the reaction types.
Topics & Concepts
ChemistryHydrogen–deuterium exchangeDeuteriumHydrogenOrganic chemistryPhysicsNuclear physicsChemical Reactions and IsotopesCold Fusion and Nuclear Reactions