Enantioselective Dual Catalysis of <i>N</i>‐Heterocyclic Carbene and Hydrogen‐Bond Donor Organocatalysts
Hongling Wang, Yonggui Robin, Xuan Huang
Abstract
Abstract N ‐heterocyclic carbene (NHC) catalysis has become a versatile catalysis strategy for building molecules via unique reaction modes. Dual catalytic processes using NHCs in combination with additional modulating agents such as another organocatalyst or transition‐metal catalyst have also been studied. The clear selection of cocatalysts has led to enhanced reactivity, increased yields, and/or improved stereoselectivity. This minireview is to provide readers with a brief overview of the development and applications of NHC and hydrogen‐bond donor for dual catalytic reactions.
Topics & Concepts
ChemistryCarbeneEnantioselective synthesisCatalysisOrganocatalysisReactivity (psychology)Combinatorial chemistryStereoselectivityHydrogen bondHomogeneous catalysisOrganic chemistrySynergistic catalysisMoleculeAlternative medicineMedicinePathologyN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods