Structural characterization of<i>Poria cocos</i>oligosaccharides and their effects on the hepatic metabolome in high-fat diet-fed mice
Lin Zhu, Guangming Chen, Yanlei Guo, Junping Zheng, Huabing Yang, Xiongjie Sun, Yang Liu, Baifei Hu, Hongtao Liu
Abstract
. Using an HFD-fed mouse model with dyslipidemia, PCO could significantly suppress lipid metabolism disorders, characterized by the reduction of lipid accumulation and inflammatory responses in the blood and liver tissues. Based on the non-targeted metabolomic analysis and Spearman's correlation analysis, we presume that the preventive effect of PCO on dyslipidemia might contribute to the reversal of changed metabolic pathways, which were related to the metabolisms of glycerophospholipids, unsaturated fatty acids, amino acids, choline, bile acids, tryptophan, sphingolipids, and glutathione. Our research shed light on the potential application of PCO for the treatment of dyslipidemia.