Quantitative Evaluation of the Effect of Antigen Expression Level on Antibody–Drug Conjugate Exposure in Solid Tumor
David Bussing, Sharad Sharma, Zhe Li, Lyndsey F. Meyer, Dhaval K. Shah
Topics & Concepts
In vivoAntibody-drug conjugateAntigenConjugateIn vitroTrastuzumabAntibodyPharmacokineticsChemistryCytotoxic T cellPayload (computing)Cancer researchPharmacologyCancerImmunologyMedicineMonoclonal antibodyBiologyInternal medicineBiochemistryComputer scienceMathematicsBiotechnologyMathematical analysisBreast cancerNetwork packetComputer networkHER2/EGFR in Cancer ResearchMonoclonal and Polyclonal Antibodies ResearchRadiopharmaceutical Chemistry and Applications