KRT8 (keratin 8) attenuates necrotic cell death by facilitating mitochondrial fission-mediated mitophagy through interaction with PLEC (plectin)
Ahruem Baek, Sumin Son, Yu Mi Baek, Dong‐Eun Kim
Abstract
3-MA: 3-methyladenine; AMD: age-related macular degeneration; DDIT3: DNA damage inducible transcript 3; DNM1L: dynamin 1 like; ER: endoplasmic reticulum; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GCN1: GCN1 activator of EIF2AK4; IF: intermediate filament; KRT8: keratin 8; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3; MFF: mitochondrial fission factor; MMP: mitochondrial membrane potential; OCR: oxygen consumption rate; PLEC: plectin; ROS: reactive oxygen species; RPE: retinal pigment epithelium; SQSTM1/p62: sequestosome 1; TOMM20: translocase of outer mitochondrial membrane 20.
Topics & Concepts
MitophagyCell biologyMitochondrionBiologyMitochondrial fissionProgrammed cell deathAutophagyBiochemistryApoptosisAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseBiomedical Research and Pathophysiology