Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity
Aisha Sethi, Mahmood Ahmad, Tayyaba Huma, Waqas Ahmad
Abstract
= 0.326-0.256). The optimized formulation (5-FU6) was observed under DSC/TGA, TEM. PXRD curves, FTIR, which confirmed thermal stability, structural integrity, amorphous state, compatibility between drug and polymer of optimized (5-FU6) as well as reduced acute oral toxicity in albino rabbits. Cross-linked medium molecular weight chitosan nanoparticles are nontoxic, well-tolerated therefore could be the future candidate for therapeutic effects as novel drug delivery carrier for anticancer drug(s).
Topics & Concepts
BioavailabilityGlutaraldehydeChitosanZeta potentialMaterials scienceNanoparticlePharmacokineticsParticle sizePermeationDissolution testingChromatographyNuclear chemistryChemistryPharmacologyNanotechnologyOrganic chemistryMedicineBiochemistryBiopharmaceutics Classification SystemPhysical chemistryMembraneAdvanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery Systems