Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis
Cait A. Beddows, Garron T. Dodd
Abstract
Insulin signals to the brain where it coordinates multiple physiological processes underlying energy and glucose homeostasis. This review explores where and how insulin interacts within the brain parenchyma, how brain insulin signalling functions to coordinate energy and glucose homeostasis and how this contributes to the pathogenesis of metabolic disease.
Topics & Concepts
InsulinHomeostasisGlucose homeostasisEndocrinologyEnergy homeostasisInternal medicineInsulin receptorPathogenesisParenchymaEnergy metabolismBiologyMedicineInsulin resistanceObesityBotanyRegulation of Appetite and ObesityMetabolism, Diabetes, and CancerPancreatic function and diabetes