Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors
Hongru Zhang, Pengfei Yu, Vivek S. Tomar, Xiangjie Chen, Matthew J. Atherton, Zhen Lu, Hong-Guang Zhang, Shifeng Li, Angélica Ortiz, Jun Gui, N. Adrian Leu, Fangxue Yan, Andrés Blanco, Mirella L. Meyer‐Ficca, Ralph G. Meyer, Daniel P. Beiting, Jinyang Li, Selene Nuñez-Cruz, Roddy S. O’Connor, Lexus R. Johnson, Andy J. Minn, Subin S. George, Constantinos Koumenis, J. Alan Diehl, Michael C. Milone, Hui Zheng, Serge Y. Fuchs
Topics & Concepts
Tumor microenvironmentChimeric antigen receptorCancer researchCytotoxic T cellImmunosuppressionCD8ImmunologyImmune systemCTL*ImmunotherapyBiologyAntigenBiochemistryIn vitroCAR-T cell therapy researchPARP inhibition in cancer therapyImmune Cell Function and Interaction