Litcius/Paper detail

Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors

Hongru Zhang, Pengfei Yu, Vivek S. Tomar, Xiangjie Chen, Matthew J. Atherton, Zhen Lu, Hong-Guang Zhang, Shifeng Li, Angélica Ortiz, Jun Gui, N. Adrian Leu, Fangxue Yan, Andrés Blanco, Mirella L. Meyer‐Ficca, Ralph G. Meyer, Daniel P. Beiting, Jinyang Li, Selene Nuñez-Cruz, Roddy S. O’Connor, Lexus R. Johnson, Andy J. Minn, Subin S. George, Constantinos Koumenis, J. Alan Diehl, Michael C. Milone, Hui Zheng, Serge Y. Fuchs

2022Nature Cancer54 citationsDOIOpen Access PDF

Topics & Concepts

Tumor microenvironmentChimeric antigen receptorCancer researchCytotoxic T cellImmunosuppressionCD8ImmunologyImmune systemCTL*ImmunotherapyBiologyAntigenBiochemistryIn vitroCAR-T cell therapy researchPARP inhibition in cancer therapyImmune Cell Function and Interaction