Copper‐Catalyzed Radical Silylarylation of Activated Alkenes: Preparation of <i>β</i>‐Silyl Amide‐Pharmaceutical Hybrids
Fei Chen, Shiyu Liu, Xiao Li, Jia‐Lu Jia, Yi Li, Xiao‐Lan Lu, Jia Lin, Yang Zheng, Zhongfei Yan, Gang Li, Yunhe Lv, Hao‐Jie Rong, Hao‐Jie Rong
Abstract
Abstract Copper‐catalyzed silylarylation of N ‐(arylsulfonyl)acrylamides via a tandem silyl radical addition/1,4‐aryl migration/desulfonylation sequence has been developed. This method employs silanes as the precursor of silyl radical and di‐ tert ‐butyl peroxide (DTBP) as the initiator. By using this cascade procedure, a series of β ‐silyl amide‐pharmaceutical hybrids which contain an α ‐all‐carbon quaternary stereocenter were facilely synthesized.
Topics & Concepts
SilylationChemistryStereocenterAmideSilanesCatalysisTandemRadical initiatorArylPeroxideOrganic chemistryCombinatorial chemistryAlkylSilaneEnantioselective synthesisComposite materialPolymerMaterials sciencePolymerizationCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesRadical Photochemical Reactions