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Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

Wei Yang, Xiaolong Liu, Chunli Song, Sen Ji, Jianhong Yang, Yang Liu, Jing You, Jie Zhang, Shenzhen Huang, Wei Cheng, Zhenhua Shao, Linli Li, Shengyong Yang

2020European Journal of Medicinal Chemistry72 citationsDOIOpen Access PDF

Topics & Concepts

PhenothiazinePharmacologyChemistryStroke (engine)DrugLead compoundIschemic strokePharmacokineticsHT1080Programmed cell deathStructure–activity relationshipCellIn vitroMedicineIschemiaBiochemistryInternal medicineApoptosisMechanical engineeringEngineeringFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsMicroRNA in disease regulation
Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model | Litcius