Aldehydes alter TGF-β signaling and induce obesity and cancer
Xiaochun Yang, Krishanu Bhowmick, Shuyun Rao, Xiyan Xiang, Kazufumi Ohshiro, Richard Amdur, Md. Imtaiyaz Hassan, Taj Mohammad, Keith A. Crandall, Paolo Cifani, Kirti Shetty, Scott K. Lyons, Joseph R. Merrill, Anil K. Vegesna, Sahara John, Patricia S. Latham, James M. Crawford, Bibhuti Nath Mishra, Srinivasan Dasarathy, Xin Wei Wang, Herbert Yu, Zhanwei Wang, Hai Huang, Adrian R. Krainer, Lopa Mishra
Abstract
mice. This study identifies SPTBN1 as a critical regulator of the functional phenotype of toxic aldehyde-induced MASH and a potential therapeutic target.
Topics & Concepts
ObesityTransforming growth factorSignal transductionCancerCancer researchCell biologyMedicineChemistryInternal medicineBiologyEndocrinologyDiet and metabolism studiesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism