Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
Inês Castela, Juliana Morais, Inês Barreiros-Mota, Marta P. Silvestre, Cláudia Marques, Catarina Rodrigues, Shámila Ismael, João R. Araújo, Miguel Ângelo‐Dias, Catarina Martins, Luís Miguel Borrego, Rosário Monteiro, Sílvia R. Coutinho, Conceição Calhau, Cátia Martins, Ana Faria, Diogo Pestana, Diana Teixeira
Abstract
Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature of the pathophysiology of obesity and insulin resistance. Early identification of individuals at higher risk of developing metabolic complications through adipose tissue dysfunction assessment and the staging of obesity and its transient phenotypes can contribute to improve therapeutic decision-making.