BF<sub>3</sub>·Et<sub>2</sub>O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant
Zhenli Luo, Yixiao Pan, Zhen Yao, Ji Yang, Xin Zhang, Xintong Liu, Lijin Xu, Qing‐Hua Fan
Abstract
A versatile metal- and base-free direct reductive amination of aldehydes with primary and secondary amines catalyzed by inexpensive BF<sub>3</sub>·Et<sub>2</sub>O using formic acid as a reductant has been developed.
Topics & Concepts
Reductive aminationFormic acidCatalysisAminationChemistryMetalOrganic chemistryCombinatorial chemistryAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsCarbon dioxide utilization in catalysis