Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4
Tammie Bishop, Peter J. Ratcliffe
Abstract
show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sensitivity to hypoxia.
Topics & Concepts
Carotid bodyGene isoformCytochrome c oxidaseProtein subunitOxygenOxidase testCytochromeBiologyChemistryCell biologyBiochemistryEnzymeMolecular biologyGeneMedicineInternal medicineCarotid arteriesOrganic chemistryCancer, Hypoxia, and MetabolismHigh Altitude and HypoxiaNeuroscience of respiration and sleep