Host-dependent heterologous expression of berninamycin gene cluster leads to linear thiopeptide antibiotics
Bidhan Chandra De, Wenjun Zhang, Guangtao Zhang, Zhiwen Liu, Bin Tan, Qingbo Zhang, Liping Zhang, Haibo Zhang, Yiguang Zhu, Changsheng Zhang
Abstract
Linearized berninamycin analogues were generated by heterologous expression of the ber biosynthetic gene cluster from deep-sea derived Streptomyces sp. SCSIO 11878 in S. albus , but neither in S. lividans nor in S. coelicolor .
Topics & Concepts
Streptomyces coelicolorStreptomycesChemistryStreptomyces albusHeterologous expressionGene clusterHeterologousStereochemistryStreptomycetaceaeGeneBacteriaActinomycetalesBiochemistryGeneticsBiologyRecombinant DNAMicrobial Natural Products and BiosynthesisChemical Synthesis and AnalysisRNA and protein synthesis mechanisms