Exosomal miR-183-5p promotes angiogenesis in colorectal cancer by regulation of FOXO1
Anquan Shang, Xuan Wang, Chenzheng Gu, Wenfang Liu, Junjun Sun, Bingjie Zeng, Chen Chen, Ping Ji, Junlu Wu, Wenqiang Quan, Yiwen Yao, Weiwei Wang, Zujun Sun, Dong Li
Abstract
experiments confirmed the tumor-promotive effects of CRC cell-derived exosomal miR-183-5p. Collectively, our study demonstrates that the CRC cell-derived exosomes overexpressing miR-183-5p aggravates CRC through the regulation of FOXO1. Exosomes overexpressing miR-183-5p might be a potential treatment biomarker for CRC.
Topics & Concepts
AngiogenesisColorectal cancerCancer researchFOXO1MedicinemicroRNACancerOncologyInternal medicineBiologySignal transductionCell biologyGeneGeneticsProtein kinase BExtracellular vesicles in diseaseCircular RNAs in diseasesMicroRNA in disease regulation