Visualization of HOCl in the brains of Alzheimer's disease models using an easily available two-photon fluorogenic probe
Jia Ke, Peixu Zhao, Jianfeng Li, Qiang Fu
Abstract
two-photon imaging. Importantly, we monitored the elevated level of HOCl in AD brains compared to normal brains. Ultimately, based on the two-photon imaging of the hippocampus of brain slices and Morris water maze test, the cognitive ability of the AD model mice was effectually ameliorated by treatment with an MPO inhibitor. Thus, we expect that the Q-HOCl probe can be applied to reveal the capacity of HOCl in AD pathology and develop efficacious MPO inhibitor drugs for the treatment of AD.
Topics & Concepts
VisualizationPhotonDiseaseTwo-photon excitation microscopyNeuroscienceComputer scienceChemistryNanotechnologyMaterials scienceMedicinePathologyArtificial intelligencePhysicsPsychologyFluorescenceOpticsNitric Oxide and Endothelin EffectsTraumatic Brain Injury and Neurovascular DisturbancesRetinal Diseases and Treatments