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Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill

Xiaolei Xie, Guangan He, Zahid H. Siddik

2020Molecular Pharmacology13 citationsDOIOpen Access PDF

Topics & Concepts

RAD51RecombinaseHomologous recombinationCisplatinRecombinationAugmentHomologous chromosomeCell biologyChemistryBiologyMolecular biologyGeneticsDNAGeneChemotherapyPhilosophyLinguisticsDNA Repair MechanismsCancer-related Molecular PathwaysMicrotubule and mitosis dynamics
Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill | Litcius