Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1-FoxO1-SREBP2 pathway for cholesterol synthesis
Mengya Shan, Ying Dai, Xiaodan Ren, Jing Zheng, Ke-bin Zhang, Bin Chen, Jun Yan, Zihui Xu
Topics & Concepts
SteatosisBerberineFOXO1CholesterolMedicineInternal medicineSirtuin 1Nonalcoholic steatohepatitisLiver X receptorNonalcoholic fatty liver diseaseEndocrinologyPharmacologyChemistryDownregulation and upregulationBiochemistryFatty liverGeneTranscription factorDiseaseNuclear receptorBerberine and alkaloids researchLiver physiology and pathologyDrug-Induced Hepatotoxicity and Protection