Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells
Yanling Zhu, Zhishuai Zhang, Nana Fan, Ke Huang, Hao Li, Jiaming Gu, Quanjun Zhang, Zhen Ouyang, Tian Zhang, Jun Tang, Yanqi Zhang, Yangyang Suo, Chengdan Lai, Jiaowei Wang, Junwei Wang, Yongli Shan, Mingquan Wang, Qianyu Chen, Tiancheng Zhou, Liangxue Lai, Guangjin Pan
Abstract
cells further gave rise to various subtype blood cells in a typical colony-forming unit (CFU) assay. Thus, we provide proof of concept to obtain functional human cells through enhanced interspecies chimerism with hPSCs.
Topics & Concepts
Chimera (genetics)BiologyInduced pluripotent stem cellEmbryonic stem cellCell biologyKOSRStem cellProgenitor cellTeratomaImmunologyMolecular biologyGeneticsGenePathologyMedicinePluripotent Stem Cells ResearchCRISPR and Genetic EngineeringRenal and related cancers