Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine
Jakub Staroń, Wojciech Pietruś, Ryszard Bugno, Rafał Kurczab, Grzegorz Satała, Dawid Warszycki, Tomasz Lenda, Anna Wantuch, Adam S. Hogendorf, Agata Hogendorf, Beata Duszyńska, Andrzej J. Bojarski
Topics & Concepts
ChemistryFluvoxamineHalogenFluoxetineSerotonin transporterBromineHalogen bondFluorineStereochemistryParoxetineBenzothiazoleMedicinal chemistrySerotoninOrganic chemistryBiochemistryReceptorAlkylComputational Drug Discovery MethodsPhenothiazines and Benzothiazines Synthesis and ActivitiesPharmacological Receptor Mechanisms and Effects