MUC1-C is necessary for SHP2 activation and BRAF inhibitor resistance in BRAF(V600E) mutant colorectal cancer
Yoshihiro Morimoto, Nami Yamashita, Haruka Hirose, Atsushi Fushimi, Naoki Haratake, Tatsuaki Daimon, Atrayee Bhattacharya, Rehan Ahmad, Yozo Suzuki, Hidekazu Takahashi, Donald Küfe
Topics & Concepts
Cancer researchMAPK/ERK pathwayV600EMEK inhibitorMedicineSignal transductionKinaseCancerColorectal cancerMUC1BiologyMutationInternal medicineCell biologyGeneticsGeneProtein Tyrosine PhosphatasesGlycosylation and Glycoproteins ResearchPI3K/AKT/mTOR signaling in cancer