Prognostic impact of at least 12 lymph nodes after neoadjuvant therapy in rectal cancer: A meta-analysis
Ling Tan, Haohuan Li, Zhou Ma, He Zhou, Lin-Han Tang, Yilei Liu, Jiangwei Xiao
Abstract
BACKGROUND: The number of dissected lymph nodes (LNs) in rectal cancer after neoadjuvant therapy has a controversial effect on the prognosis. AIM: To investigate the prognostic impact of the number of LN dissected in rectal cancer patients after neoadjuvant therapy. METHODS: LNs < 12). The primary endpoints were the overall survival (OS) and disease-free survival (DFS). RESULTS: = 0.565) between the LNs ≥ 12 and LNs < 12 groups. CONCLUSION: Although neoadjuvant therapy reduces LN production in rectal cancer, our data indicate that dissecting at least 12 LNs after neoadjuvant therapy may improve the patients' OS, DFS, and DR.
Topics & Concepts
MedicineColorectal cancerMeta-analysisNeoadjuvant therapyLymphOncologyInternal medicineCancerSurgeryRadiologyPathologyBreast cancerColorectal Cancer Surgical TreatmentsColorectal and Anal CarcinomasColorectal Cancer Screening and Detection