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Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7

Feng Yao, Bing Zhang, Jialun Lv, Peng Zhang, Qing Mao, Fengwei Lin, Jiaxing Zhao, Xuefeng Fu, Yajun Yang, Zhaolin Li, Lei Zhang, Yanhua Mou, Shaojie Wang

2022European Journal of Medicinal Chemistry19 citationsDOI

Topics & Concepts

ChemistryMCF-7Cyclin-dependent kinaseCell cultureMTT assayAutophagyCancer cellCell growthCell cycle checkpointCell biologyCell cycleApoptosisCancer researchBiochemistryCancerHuman breastBiologyGeneticsNatural Compounds in Disease TreatmentAutophagy in Disease and TherapyCell death mechanisms and regulation
Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7 | Litcius