A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells
Arthur Bister, Tabea C. Ibach, Corinna Haist, Denise Smorra, Katharina Roellecke, Martin Wagenmann, Kathrin Scheckenbach, Norbert Gattermann, Constanze Wiek, Helmut Hanenberg
Abstract
experiments in NSG mice. We also showed that the C6 hinge can be used for a variety of different CARs and mediates high killing efficacy without unspecific activation by target antigen-negative cells, thus making C6 ideally suited as a universal hinge for CARs for clinical applications.
Topics & Concepts
HingeChemistryCell biologyComputational biologyBiologyEngineeringStructural engineeringCAR-T cell therapy researchNanowire Synthesis and ApplicationsViral Infectious Diseases and Gene Expression in Insects