Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections
Tram Le, Sue C. Nang, Jinxin Zhao, Heidi H. Yu, Jian Li, Jason J. Gill, Mei Liu, Saima Aslam
Abstract
Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/mortality. Novel antibiotic alternatives to reduce UTI recurrence are critically needed. We describe a case of rUTI due to extended spectrum beta lactamase (ESBL) Klebsiella pneumoniae in a KTR that was treated successfully with 4 weeks of adjunctive intravenous bacteriophage therapy alone, without concomitant antibiotics, and with no recurrence in a year of follow-up.
Topics & Concepts
Urinary systemMedicineAntibioticsDrug resistanceDrugIntensive care medicineKidney transplantationPhage therapyMultiple drug resistanceInternal medicinePharmacologyTransplantationMicrobiologyBiologyBacteriophageEscherichia coliGeneBiochemistryBacteriophages and microbial interactionsAntibiotic Resistance in BacteriaRenal Transplantation Outcomes and Treatments