Enantiomeric β-sheet peptides from Aβ form homochiral pleated β-sheets rather than heterochiral rippled β-sheets
Xingyue Li, Stephanie E. Rios, James S. Nowick
Abstract
-1a is composed of two homochiral dimers. Collectively, these NMR studies of Aβ-derived peptides provide compelling evidence that enantiomeric β-sheet peptides prefer to self-assemble in a homochiral fashion in aqueous solution.
Topics & Concepts
EnantiomerBeta sheetAqueous solutionChemistryStereochemistryCrystallographyPolymer scienceOrganic chemistryPeptideBiochemistryChemical Synthesis and AnalysisSupramolecular Self-Assembly in MaterialsProtein Structure and Dynamics