Diastereoselective metabolism of homomenthyl salicylate (homosalate): Identification of relevant human exposure biomarkers
Katharina E. Ebert, Peter Griem, Tobias Weiß, Thomas Brüning, Heiko Hayen, Holger M. Koch, Daniel Bury
Abstract
) for the metabolites derived from trans-HMS (6.4 %) was two orders of magnitude higher than for the metabolites derived from cis-HMS (0.045 %). Our data proves diastereoselectivity in toxicokinetics of cis- and trans-HMS, emphasizing the necessity to address isomer ratios in future studies including HMS exposure and risk assessments.
Topics & Concepts
MetaboliteChemistryUrineMetabolismBioavailabilityToxicokineticsChromatographyExcretionMetabolic pathwayCarboxylic acidUrinary systemIsotope dilutionBiochemistryPharmacologyMass spectrometryEndocrinologyBiologySkin Protection and AgingEffects and risks of endocrine disrupting chemicalsAnimal testing and alternatives