ISG15 Is a Novel Regulator of Lipid Metabolism during <i>Vaccinia Virus</i> Infection
Manuel Albert, Jesús Vázquez, Juan Manuel Falcón‐Pérez, Marı́a A. Balboa, Marc Liesa, Jesús Balsinde, Susana Guerra
Abstract
The functions of ISG15 are continuously expanding, and growing evidence supports its role as a relevant modulator of cell metabolism. In this work, we highlight how the absence of ISG15 impacts macrophage lipid metabolism in the context of viral infections and how poxviruses modulate metabolism to ensure successful replication. Our results open the door to new advances in the comprehension of macrophage immunometabolism and the interaction between VACV and the host.
Topics & Concepts
Context (archaeology)BiologyVacciniaISG15Lipid metabolismVirologyMetabolismViral replicationRegulatorMacrophageVirusCell metabolismCell biologyImmunologyGeneticsGeneBiochemistryRecombinant DNAPaleontologyIn vitroUbiquitininterferon and immune responsesInfluenza Virus Research StudiesEndoplasmic Reticulum Stress and Disease