FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites
Win Lwin Thuya, Li Ren Kong, Nicholas Syn, Ling‐Wen Ding, Esther Sok Hwee Cheow, Regina Tong Xin Wong, Tingting Wang, Robby Miguel Goh, Hongyan Song, Migara Kavishka Jayasinghe, Minh T. N. Le, Jian Hu, Wei Peng Yong, Soo Chin Lee, Andrea Li‐Ann Wong, Gautam Sethi, Huynh The Hung, Paul C. Ho, Jean Paul Thiery, Siu Kwan Sze, Tiannan Guo, Ross A. Soo, Henry Yang, Yaw Chyn Lim, Lingzhi Wang, Boon-Cher Goh
Abstract
: Our study describes a novel mechanism for FAM3C-driven carcinogenesis and shed light on EV FAM3C as a driver for metastatic lung tumors that could be exploited for cancer therapeutics.
Topics & Concepts
Cancer researchBiologyMetastasisLung cancerCarcinogenesisTumor progressionTranscriptomeCancerImmunologyPathologyGene expressionMedicineGeneBiochemistryGeneticsExtracellular vesicles in diseaseMicroRNA in disease regulationRNA modifications and cancer