Blazing a trail for the clinical use of rapamycin as a geroprotecTOR
Adam R. Konopka, Dudley W. Lamming, RAP PAC Investigators, Brittany A. Grasso, Rebecca C. Marrah, Sara Decker, Neetika Garg, Yeonhee Park, Sin Yin Lim, Judith A. Simcox, Cara L. Green, Isaac Grunow, EVERLAST Investigators, Amanjot K. Yadev, Rebecca C. Marrah, Brittany A. Grasso, Sara Decker, Samantha Pabich, Didier A. Mandelbrot, Thomas R. Wallhaus, Oliver Wieben, Fay Osman, Richard J. Chappell, Irene M. Ong, Reid S. Alisch, Judith A. Simcox, Christian J. Elliehausen, Dennis M. Minton, Michaela E. Trautman, Alma Spahic, Barbara B. Bendlin, Sanjay Asthana, Alexey V. Terskikh
Topics & Concepts
mTORC1mTORC2PI3K/AKT/mTOR pathwayMechanistic target of rapamycinPharmacologyClinical trialTherapeutic windowDosingMedicinePharmacodynamicsPharmacokineticsBioinformaticsBiologySignal transductionGeneticsGenetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancerCoenzyme Q10 studies and effects