Injectable thermosensitive hydrogel to enhance the photothermal ablation and systemic immunotherapy of breast tumors
Tao Qin, Ruipeng Li, Huiqin Jin, Yunxia Wang, Liheng Feng
Abstract
killing combined with heat-released R837 can trigger robust immune response to inhibit and kill metastasis tumors. The developed AMDR hydrogel is successfully applied in the treatment of primary tumors and inhibition of distal tumors of tumor-bearing mice. The study provides a novel strategy and platform for complete treatment of breast cancer and also offers ideas for designing high-efficiency photothermal agents.
Topics & Concepts
Photothermal therapyImmunogenic cell deathCancer researchImmunogenicityDoxorubicinDoxorubicin HydrochlorideImmunotherapyBreast cancerAdjuvantCancer cellHeLaCancerMetastasisImmune systemMedicineChemistryCellChemotherapyMaterials scienceImmunologyNanotechnologyInternal medicineBiochemistryNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesPhotodynamic Therapy Research Studies