The gut microbiota during the progression of atherosclerosis in the perimenopausal period shows specific compositional changes and significant correlations with circulating lipid metabolites
Qinghai Meng, Meng-Hua Ma, Weiwei Zhang, Yunhui Bi, Peng Cheng, Xichao Yu, Yu Fu, Ying Chao, Tingting Ji, Jun Li, Qi Chen, Qichun Zhang, Yu Li, Jinjun Shan, Huimin Bian
Abstract
mice. Moreover, the gut microbiota and lipid metabolites were significantly correlated, demonstrating that the changes of serum lipids may be associated with the gut microbiota disruptions in the perimenopausal period. In conclusion, the gut microbiota during the progression of AS in the perimenopausal period showed specific compositional changes and significant correlations with circulating lipid metabolites. Estrogen supplementation may exert beneficial effects on gut bacteria and lipid metabolism.
Topics & Concepts
Ovariectomized ratEndocrinologyInternal medicineBiologyGut floraLipid metabolismMenopauseEstrogenCholesterolApolipoprotein EImmunologyDiseaseMedicineGut microbiota and healthDiet and metabolism studiesDietary Effects on Health