OXPHOS bioenergetic compensation does not explain disease penetrance in Leber hereditary optic neuropathy
M. Isabel G. Lopez Sanchez, Nicole J. Van Bergen, Lisa S. Kearns, Mark Ziemann, Helena H. Liang, Alex W. Hewitt, David A. Mackey, Ian A. Trounce
Topics & Concepts
BiologyBioenergeticsMitochondrial DNAPenetranceMitochondrionMitochondrial diseaseGene knockdownGlycolysisPhenotypeCell biologyDownregulation and upregulationPoint mutationLeber's hereditary optic neuropathyGeneticsMutationEndocrinologyGeneMetabolismMitochondrial Function and PathologyATP Synthase and ATPases ResearchPhotosynthetic Processes and Mechanisms