Molecular Properties of New Enzyme Rhodopsins with Phosphodiesterase Activity
Masahiro Sugiura, Satoshi P. Tsunoda, Masahiko Hibi, Hideki Kandori
Abstract
Rh-PDE, did not contain the retinal-binding Lys at TM7 and showed cAMP-specific PDE activity both in the dark and light. These results provide mechanistic insight into rhodopsin-mediated, light-dependent regulation of second-messenger levels in eukaryotic microbes.
Topics & Concepts
PhosphodiesteraseRhodopsinEnzymePDE10APhosphodiesterase 3Second messenger systemCyclic nucleotide phosphodiesteraseBiochemistryNucleotideCyclic nucleotideBiologyEnzyme activatorBiophysicsChemistryGeneRetinalPhotoreceptor and optogenetics researchRetinal Development and DisordersMolecular Communication and Nanonetworks