The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications
Jéssica Manoelli Costa da Silva, Eliel Barbosa Teixeira, Ronald Matheus da Silva Mourão, Rafaella Sousa Ferraz, Fabiano Cordeiro Moreira, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno
Abstract
Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.