Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal
Sanhu Gou, Beibei Li, Xu Ouyang, Zufang Ba, Chao Zhong, Jingman Ni
Abstract
-butyric acid at the N-terminal, and thus exhibited the best antibacterial activity. However, the trimer had high hemolytic activity. Finally, A-C8, a simple structural lipopeptide, which is not a dendrimer, was obtained following the lipidation of anoplin using octanoic acid; it exhibited the highest therapeutic index, which makes it a probable antibiotic and thus was screened out.
Topics & Concepts
Lipid-anchored proteinTrimerAntimicrobialLysineAntibacterial activityLipopeptideChemistryPeptideAntimicrobial peptidesBiochemistryAmino acidBacteriaBiologyOrganic chemistryAutophagyGeneticsApoptosisDimerAntimicrobial Peptides and ActivitiesPolydiacetylene-based materials and applicationsChemical Synthesis and Analysis