Insulin-derived amyloidosis: The insulin ball, amyloidoma

Abstract

Insulin-derived amyloidosis is defined as a subcutaneous amyloid mass at the site of insulin injections, in which the amyloid deposit shows a positive staining result with anti-insulin antibodies.1 Most patients present with a solitary mass. Nagase et al2 referred to this as the “insulin ball,” whereas others have referred to it as an amyloidoma.3 Insulin-derived amyloidosis is relatively unknown in the dermatologic literature. We report an unusual case of a patient who presented with 4 sites of insulin-derived subcutaneous amyloidosis.

Topics & Concepts