A Cell Culture-Adapted Vaccine Virus against the Current African Swine Fever Virus Pandemic Strain
Manuel V. Borca, A. Rai, Elizabeth Ramírez-Medina, E. Silva, Lauro Velázquez-Salinas, Elizabeth A. Vuono, Sarah Pruitt, Nallely Espinoza, Douglas P. Gladue
Abstract
African swine fever is currently causing a pandemic resulting in devastating losses to the swine industry. Experimental ASF vaccines rely on the production of vaccine in primary swine macrophages, which are difficult to use for the production of a vaccine on a commercial level. Here, we report a vaccine for ASFV with a deletion in the left variable region (LVR). This deletion allows for growth in stable cell cultures while maintaining the potency and efficacy of the parental vaccine strain. This discovery will allow for the production of an ASF vaccine on a commercial scale.
Topics & Concepts
BiologyVirologyPandemicVirusStrain (injury)African swine fever virusVirus strainCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)DiseaseAnatomyPathologyMedicineAnimal Disease Management and EpidemiologyViral gastroenteritis research and epidemiologyViral Infectious Diseases and Gene Expression in Insects