Cardamonin inhibits osteogenic differentiation of human valve interstitial cells and ameliorates aortic valve calcification <i>via</i> interfering in the NF-κB/NLRP3 inflammasome pathway
Chunli Wang, Yi Xia, Linghang Qu, Yanju Liu, Xianqiong Liu, Kang Xu
Abstract
, CDM ameliorated aortic valve calcification by interfering with NLRP3 expression. Our study demonstrated that CDM inhibited the phenotypical calcific transformation of hVICs by mediating the inactivation of the NF-κB/NLRP3 inflammasome. Therefore, it is considered to be a promising natural compound for use in preventing the progression of heart valve calcification disease.
Topics & Concepts
RUNX2CalcificationCell biologyChemistryAortic valveBone morphogenetic protein 2Cancer researchSignal transductionBiologyGene expressionInternal medicineMedicineBiochemistryIn vitroGeneCardiac Valve Diseases and TreatmentsGout, Hyperuricemia, Uric AcidAortic Disease and Treatment Approaches