Microneedle Array Patches Integrated with Nanoparticles for Therapy and Diagnosis
Xiuli Hu, Huijuan Zhang, Zejun Wang, Chin Ying Angela Shiu, Zhen Gu
Abstract
Microneedle (MN)‐based techniques are widely explored these years for biomedical applications due to their convenience, high efficiency, and excellent patient compliance. The combination of MN array patches with nanoparticles (NPs) expands the applications of MNs with dynamic characteristics and facilitates on‐demand drug release while reducing systemic toxicity and enhancing therapeutic efficacy. This review summarizes the recent advances of MNs integrated with NPs as a transdermal approach for various applications. Representative therapeutic or diagnostic studies associated with diabetes, cancer, vaccine, obesity, hair growth, and acne vulgaris are highlighted in detail. Future perspectives for such theranostic devices in biomedical fields are also discussed.